IDI1 — Isopentenyl-diphosphate delta isomerase 1
IDI1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IDI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Plasma cell secretory B cell maturation | AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, MEPCE +9 more | View in SCUBA |
| Gamma-delta T cells | ER Proteotoxic Stress Stress | ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more | |
| Glial cells | Inflammatory Activation Response Inflammation | ANGPTL4, C11orf96, CD83, CEBPD, ENY2, GEM, IRF9, LMO4 +3 more | View in SCUBA |
| Innate lymphoid cells | Transcriptional Activation DNA regulation & transcription | AKIRIN1, CHORDC1, FAM133B, FAM53C, GOLGB1, GTF2B, MORF4L2, NABP1 +9 more | View in SCUBA |
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Stress UPR Stress | DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, LDHA, MAP1LC3B +9 more |
About the gene
| Chromosome | 10: 1039152-1049119 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Isomerase |
| Biological process | Cholesterol biosynthesis, Cholesterol metabolism, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Function
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.