Macrophage Lipid Sensing
Gene co-expression module in Macrophages
| Category | Lipid metabolism |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
Key hub genes point to multiple programs: WIPI2 is a core autophagy regulator (PI3P effector at phagophore); BIRC2 (cIAP1) is an E3 ligase regulating NF-κB and apoptosis; GPR183 (EBI2) is an oxysterol receptor critical for macrophage/B-cell positioning and is enriched in mono_mac; THEMIS2 is an immune signaling adaptor expressed in myeloid cells; IDI1 encodes isopentenyl diphosphate isomerase in the mevalonate/isoprenoid pathway; ARL4A/ARL4C are ARF-like GTPases involved in membrane trafficking; DDX21/DDX24/DDX27 are RNA helicases; NR1D2 is a nuclear receptor (Rev-erbβ) regulating circadian and inflammatory programs in macrophages. The mono_mac enrichment of GPR183, THEMIS2, ARL4C, and MIDN suggests macrophage-state specificity. The module is mixed but the strongest coherent sub-theme is macrophage lipid/oxysterol sensing and autophagy regulation.
Genes
ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183, IDI1, LMNA, LYSMD3, MED29, MIDN, NR1D2, SEC14L1, THEMIS2, TMEM50B, UAP1, WIPI2, XBP1, ZFP91
Most correlated modules
- General Cellular Maintenance · correlation 0.94
- Ubiquitin-ERAD Proteostasis · correlation 0.94
- RNA Processing Regulation · correlation 0.93
- ER-Golgi Trafficking · correlation 0.93
- Anti-inflammatory Response · correlation 0.92
- NF-κB Activation · correlation 0.92
- Splicing Factor Regulation · correlation 0.90
- Autophagy Vesicle Trafficking · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.