CHRNE — Cholinergic receptor nicotinic epsilon subunit
CHRNE belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHRNE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, ERRFI1, IL1R1 +6 more | View in SCUBA |
About the gene
| Synonyms | ACHRE |
|---|---|
| Chromosome | 17: 4897771-4934438 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Ion transport, Transport |
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.