B3GNT5 — UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
B3GNT5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
B3GNT5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory EC Activation Inflammation | ANGPT2, BAIAP2, EPHA2, GMFB, HIC1, HMOX1, JUP, LPIN2 +6 more | View in SCUBA |
| Monocytes | TREM1 Inflammatory Signaling Innate immunity | AGO2, AKAP12, ATP2B1, BTG1, C17orf107, CHRNE, ERRFI1, IL1R1 +6 more | View in SCUBA |
| Neutrophils | Neutrophil Adhesion Signaling Migration & adhesion | ETS2, GK, ICAM1, LCP2, PDE4B, SKIL, ZNF267 | |
| Pericytes | EMT-like Remodeling ECM remodeling | APOLD1, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RALGDS, RND1 +2 more | View in SCUBA |
About the gene
| Synonyms | B3GN-T5, beta3Gn-T5 |
|---|---|
| Chromosome | 3: 183253253-183298504 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Developmental protein, Glycosyltransferase, Transferase |
| Biological process | Lipid metabolism |
Function
Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.