TREM1 Inflammatory Signaling
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
TREM1 is a potent amplifier of innate immune inflammatory signaling in monocytes/macrophages. IL1R1 is the IL-1 receptor, central to inflammatory cytokine signaling. ITGAX (CD11c) marks inflammatory/non-classical monocytes and dendritic cells. TNFRSF1B (TNFR2) mediates TNF signaling. PDE4A regulates cAMP in myeloid cells. ERRFI1 is an EGFR feedback inhibitor induced by inflammation. BTG1 is an anti-proliferative gene. AGO2 is the core RISC endonuclease involved in miRNA-mediated gene regulation. LPCAT1 is involved in phospholipid remodeling. AKAP12 is a scaffold for PKA/PKC. The module is upregulated in IBD inflammation and reversed in remission, consistent with TREM1-amplified inflammatory monocyte activation with cytokine receptor signaling.
Genes
AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1, IL1R1, ITGAX, LPCAT1, PDE4A, SLC43A2, TNFRSF1B, TREM1
Most correlated modules
- Monocyte Immune Tolerance · correlation 0.81
- Wnt/AP-1 Activation · correlation 0.76
- NLRP3 Inflammasome Activation · correlation 0.74
- Complement Receptor Activation · correlation 0.73
- Fc Receptor Activation · correlation 0.72
- Hypoxia Response · correlation 0.70
- TNF-driven Activation · correlation 0.69
- Inflammatory Metabolic Reprogramming · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.