CLPTM1 — CLPTM1 regulator of GABA type A receptor forward trafficking
CLPTM1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLPTM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Actin Cytoskeletal Regulation Cytoskeleton & motility | AQP3, CCDC57, COTL1, DCAF11, GSN, GYG1, MZT2B, NAA38 +7 more | View in SCUBA |
About the gene
| Chromosome | 19: 44954585-44993341 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Developmental protein |
| Biological process | Differentiation |
Function
Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI- anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.