Actin Cytoskeletal Regulation
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 16 genes have a known function matching the annotation |
Why this annotation
This weak-coherence module has strong ILC1 enrichment (2.2–5.8x). Hub genes include NAA38 (N-terminal acetyltransferase), DCAF11 (ubiquitin ligase adaptor), CCDC57 (coiled-coil domain protein), GSN (gelsolin, actin-severing/cytoskeletal), COTL1 (coactosin-like, actin binding), POMT1 (protein O-mannosyltransferase), POLR2G (RNA polymerase II subunit), PAPSS1 (PAPS synthase, sulfation), GYG1 (glycogenin, glycogen synthesis), SH3KBP1 (CIN85, endocytosis/receptor downregulation), PTPN18 (protein tyrosine phosphatase), AQP3 (aquaporin water channel), SPATS2L (RNA binding). The module is functionally heterogeneous with no single dominant pathway. GSN and COTL1 suggest cytoskeletal involvement; GYG1 suggests metabolic; PAPSS1 suggests sulfation metabolism. The overall picture is a loosely co-regulated ILC1-enriched module with cytoskeletal and metabolic elements. Given GSN and COTL1 as notable cytoskeletal genes and the weak coherence, this is tentatively labeled as a mixed ILC1 cytoskeletal/metabolic module.
Genes
AQP3, CCDC57, CLPTM1, COTL1, DCAF11, GSN, GYG1, MZT2B, NAA38, PAPSS1, POLR2G, POMT1, PTPN18, SH3KBP1, SPATS2L, ZNF428
Most correlated modules
- Mitochondrial Metabolic Housekeeping · correlation 0.95
- Oxidative Phosphorylation · correlation 0.94
- NK Cytotoxic Effector · correlation 0.91
- ILC1 Lymphocyte Signaling · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.