CTLA4 — Cytotoxic T-lymphocyte associated protein 4
CTLA4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTLA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, DNPH1, GBP2, IL2RA, NAMPT, NDFIP2, NINJ2 +6 more | View in SCUBA |
| CD8⁺ T cells | TCR Activation & Modulation Exhaustion | ADGRG1, AKAP5, ENTPD1, ETV1, GALNT2, LAYN, MAST4, SOX4 | View in SCUBA |
About the gene
| Synonyms | CD, CD152, CELIAC3, CTLA-4, GSE, IDDM12 |
|---|---|
| Chromosome | 2: 203853888-203873965 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.