AKAP5 — A-kinase anchoring protein 5
AKAP5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKAP5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1, PBXIP1 +8 more | View in SCUBA |
| CD8⁺ T cells | TCR Activation & Modulation Exhaustion | ADGRG1, CTLA4, ENTPD1, ETV1, GALNT2, LAYN, MAST4, SOX4 | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1, DGKH +20 more |
About the gene
| Synonyms | AKAP75, AKAP79 |
|---|---|
| Chromosome | 14: 64465499-64474503 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Calmodulin-binding |
Function
Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with the beta2- adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses. In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.