GALNT2 — Polypeptide N-acetylgalactosaminyltransferase 2
GALNT2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GALNT2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | TCR Activation & Modulation Exhaustion | ADGRG1, AKAP5, CTLA4, ENTPD1, ETV1, LAYN, MAST4, SOX4 | View in SCUBA |
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Glial cells | TGF-beta ECM Remodeling ECM remodeling | HCFC1R1, ITGB8, LOXL3, PDGFA, RCAN1, S1PR3, SPRY1 | View in SCUBA |
| Macrophages | Endosomal Vesicle Trafficking Vesicular traficking | ADAM17, AP3B1, ARFGEF1, ARID1B, ARK2N, ASAP1, ATF6, ATP11A +48 more | View in SCUBA |
About the gene
| Synonyms | GalNAc-T2 |
|---|---|
| Chromosome | 1: 230057990-230282122 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP. It participates in the regulation of HDL-C metabolism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.