CXCL16 — C-X-C motif chemokine ligand 16
CXCL16 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL16's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | G-protein Membrane Remodeling Migration & adhesion | ADA, ANKRD9, DNMBP, EPB41L3, GFOD1, GNA12, GNA13, MRAS +7 more | View in SCUBA |
About the gene
| Synonyms | CXCLG16, SR-PSOX, SRPSOX |
|---|---|
| Chromosome | 17: 4733533-4739928 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters |
| Molecular function | Cytokine |
| Biological process | Chemotaxis |
Function
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.