G-protein Membrane Remodeling
Gene co-expression module in Monocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes SNX9, DNMBP, EPB41L3, RAPGEF1, GNA12, GNA13 collectively drive membrane remodeling, endocytic sorting, and G-protein (RhoA) signaling. CXCL16 is a monocyte chemokine, RFTN1 links to lipid raft endocytosis, TNFRSF21 is a death receptor. The module reflects monocyte activation-associated membrane dynamics and G-protein-coupled cytoskeletal remodeling, upregulated in IBD inflammation and reduced in remission.
Genes
ADA, ANKRD9, CXCL16, DNMBP, EPB41L3, GFOD1, GNA12, GNA13, MRAS, RAPGEF1, RFTN1, SHB, SNX9, SYN1, SYTL3, TNFRSF21
Most correlated modules
- Myeloid Epigenetic Regulation · correlation 0.85
- Complement Receptor Activation · correlation 0.64
- Endosomal Sorting · correlation 0.64
- Inflammatory Cell Death · correlation 0.62
- Non-canonical NF-κB · correlation 0.60
- Wnt/AP-1 Activation · correlation 0.58
- MET Tissue Repair · correlation 0.55
- Secretory Vesicle Trafficking · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.