Rho GTPase Signaling
Gene co-expression module in Gamma-delta T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 23 genes have a known function matching the annotation |
Why this annotation
Moderate coherence with many weak/moderate membership genes. Hub genes include FIP1L1 (mRNA 3' cleavage/polyadenylation), NCOR1 (nuclear receptor corepressor, transcriptional silencing), PTK2B/PYK2 (focal adhesion/calcium-dependent tyrosine kinase), RPE (ribulose-5-phosphate-3-epimerase, pentose phosphate pathway), ARHGEF3 (RhoA/RhoB GEF), HK1 (hexokinase 1, glycolysis), ROCK1 (Rho-associated kinase), PAK2 (p21-activated kinase, downstream of Rac/Cdc42), G3BP1 (stress granule assembly), BRCC3 (deubiquitinase). The Rho-GTPase axis (ARHGEF3→RhoA→ROCK1, and PAK2 downstream of Rac) is the most coherent pathway, supported by PTK2B which activates Rho GEFs. HK1 and RPE suggest metabolic co-regulation. NCOR1 adds transcriptional repression. Moderate coherence reflects mixing of Rho signaling with metabolic and RNA processing elements. Neighbor context: shares Rho-GTPase theme with cytoskeletal modules M71 (ACTR2, CAPZA1) and M178 (IQGAP1).
Genes
APOBR, ARHGEF3, ATP6V1H, BRCC3, CD46, CNDP2, CYB5R4, DCTN5, DNMT3A, FIP1L1, G3BP1, HK1, MYNN, NCOR1, PAK2, PTK2B, RAB27A, RMDN1, ROCK1, RPE, SDCCAG8, THOC2, ZC3H13
Most correlated modules
- Actin Cytoskeletal Regulation · correlation 0.91
- Chromatin TF Regulation · correlation 0.89
- Metabolic-Translational Coupling · correlation 0.83
- mRNA Decay Trafficking · correlation 0.83
- mRNA Splicing · correlation 0.81
- mRNA Splicing Regulation · correlation 0.81
- T Cell Calcium-Cytoskeletal · correlation 0.81
- DNA Damage Response · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.