ARHGEF3 — Rho guanine nucleotide exchange factor 3
ARHGEF3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17 lineage Th17 fate | ADA, CD226, CD52, DENND3, EVL, IDH2, IL17RE, IL23R +13 more | View in SCUBA |
| Endothelial | NF-kB Chromatin Regulation DNA/chromatin regulation | DGKE, HLA-E, HOXB3, IKBKB, ITPKB, KITLG, LIMCH1, MALT1 +4 more | View in SCUBA |
| Gamma-delta T cells | Rho GTPase Signaling Cytoskeletal | APOBR, ATP6V1H, BRCC3, CD46, CNDP2, CYB5R4, DCTN5, DNMT3A +14 more | |
| Innate lymphoid cells | ILC1 Effector Activation activation | ADAM19, BATF, CD151, CDK4, FES, FURIN, HLA-F, IL22 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Survival T cell maturation | BTN3A1, CNTRL, GIMAP8, ME2, PCMTD1, PRKACB, RSBN1L, SHPRH +4 more | |
| Natural Killer cells | Cytoskeletal Remodeling Cytoskeleton & motility | ADD3, ARHGAP25, C1orf21, CAPN2, CYTH1, DGKZ, DIP2A, GBP5 +4 more | View in SCUBA |
About the gene
| Synonyms | DKFZP434F2429, GEF3, STA3, XPLN |
|---|---|
| Chromosome | 3: 56727418-57079329 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Acts as a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.