DENND6A — DENN domain containing 6A
DENND6A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND6A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Centrosome Organization DNA/chromatin regulation | AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DMTF1 +23 more | |
| Mucosal-associated invariant T cell | Epigenetic Maintenance DNA/chromatin regulation | ATAD2B, ATXN10, DGLUCY, DMTF1, FYCO1, GALK2, HDLBP, HELZ +13 more |
About the gene
| Synonyms | AFI1A, FAM116A, FLJ34969 |
|---|---|
| Chromosome | 3: 57625454-57693077 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.