DMTF1 — Cyclin D binding myb like transcription factor 1
DMTF1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DMTF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Centrosome Organization DNA/chromatin regulation | AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A +23 more | |
| Macrophages | Pre-mRNA Splicing Housekeeping | AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, FAM133B +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Epigenetic Maintenance DNA/chromatin regulation | ATAD2B, ATXN10, DENND6A, DGLUCY, FYCO1, GALK2, HDLBP, HELZ +13 more |
About the gene
| Synonyms | DMP1, DMTF, hDMP1, MRUL |
|---|---|
| Chromosome | 7: 87152409-87196337 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53- dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.