Epigenetic Maintenance
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include SETD2 and SETD5 (H3K36 methyltransferases), DMTF1 (chromatin-associated transcription factor), PDS5A (cohesin), alongside JAK2 and RICTOR (mTORC2 component). The module combines epigenetic regulators with broad signaling kinases in a uniformly expressed, low-detection pattern consistent with baseline epigenetic maintenance in quiescent MAIT cells. MBNL2 and HELZ contribute RNA regulatory functions. Neighbor modules similarly feature chromatin regulators and large regulatory genes, supporting a housekeeping epigenetic program.
Genes
ATAD2B, ATXN10, DENND6A, DGLUCY, DMTF1, FYCO1, GALK2, HDLBP, HELZ, JAK2, LMTK2, MBNL2, PDS5A, RICTOR, SETD2, SETD5, SUPT20H, TBC1D31, TMED10, USO1, USP9X, ZNF292
Most correlated modules
- TGF-β Immune Regulation · correlation 0.93
- Chromatin Epigenetic Regulation · correlation 0.92
- Histone Modification · correlation 0.91
- Vesicle Membrane Trafficking · correlation 0.91
- Chromatin Remodeling · correlation 0.90
- Lymphocyte Survival · correlation 0.90
- RNA Splicing Processing · correlation 0.88
- Tissue Residency · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.