Centrosome Organization
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 32 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 32 genes have a known function matching the annotation |
Why this annotation
Hub NKTR (NK/T-cell-related receptor), AKAP9 (centrosomal A-kinase anchoring protein), CEP350 (centrosome component), SETD5 (histone H3K4 methyltransferase), RICTOR (mTORC2 component), MDM4 (p53 negative regulator), REV3L (translesion DNA polymerase), TNKS2 (tankyrase, Wnt/telomere), PUM2 (post-transcriptional regulator) represent a mixed module combining centrosomal organization with chromatin/DNA regulation. Moderate coherence reflects this mixing. Centrosome genes (AKAP9, CEP350, TTC14) and chromatin regulators (SETD5, DMTF1) are the clearest sub-themes. Neighbor context with M92 and M119 (chromatin/regulatory modules) supports a related large-scale regulatory program.
Genes
AKAP9, ARMCX6, CCNT2, CEP350, CUL5, DDHD1, DDX42, DENND6A, DMTF1, DUSP6, FNBP4, GCC2, KIF9, MAN1A2, MDM4, NEMF, NKTR, PKN2, PSMB4, PUM2, RBM26, RC3H2, REV3L, RICTOR, SETD5, SRSF11, TDP1, TNKS2, TTC14, VPS13A, ZNF292, ZNF430
Most correlated modules
- Spliceosome Regulation · correlation 0.92
- T Cell Migration · correlation 0.85
- Chromatin Remodeling Signaling · correlation 0.84
- T Cell Maturation · correlation 0.83
- Mitochondrial RNA Processing · correlation 0.83
- Transcriptional Coactivation · correlation 0.81
- RNA Surveillance/NMD · correlation 0.80
- DNA Damage Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.