DTWD2 — DTW domain containing 2
DTWD2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DTWD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Eosinophil Differentiation Granulocyte development | CLC, EPX, ERN1, EXD3, IL5RA, MS4A3, PRG2 |
About the gene
| Synonyms | FLJ33977 |
|---|---|
| Chromosome | 5: 118836074-118988547 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | tRNA processing |
Function
Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)). Involved in glycoRNA biosynthesis by mediating formation of acp3U, which acts as an attachment site for N- glycans on tRNAs. GlycoRNAs consist of RNAs modified with secretory N-glycans that are presented on the cell surface.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.