EPX — Eosinophil peroxidase
EPX belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Eosinophil Differentiation Granulocyte development | CLC, DTWD2, ERN1, EXD3, IL5RA, MS4A3, PRG2 |
About the gene
| Synonyms | EPO, EPP, EPX-PEN |
|---|---|
| Chromosome | 17: 58192726-58205174 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase, Peroxidase |
| Biological process | Hydrogen peroxide |
Function
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.