PRG2 — Proteoglycan 2, pro eosinophil major basic protein
PRG2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Eosinophil Differentiation Granulocyte development | CLC, DTWD2, EPX, ERN1, EXD3, IL5RA, MS4A3 |
About the gene
| Synonyms | BMPG, MBP, proMBP |
|---|---|
| Chromosome | 11: 57386780-57390650 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | FDA approved drug targets, Plasma proteins, Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Heparin-binding |
| Biological process | Immunity |
Function
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.