Eosinophil Differentiation
Gene co-expression module in Hematopoietic progenitor cells
| Category | Granulocyte development |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
The hub genes form a definitive eosinophil differentiation signature: IL5RA (IL-5 receptor alpha, eosinophil-specific cytokine receptor), PRG2 (major basic protein, eosinophil granule protein), EPX (eosinophil peroxidase, eosinophil-specific granule enzyme), CLC (Charcot-Leyden crystal protein/galectin-10, eosinophil marker). MS4A3 marks granulocyte-monocyte progenitors. ERN1 (IRE1α) contributes UPR activity consistent with granule protein production. This is a high-confidence eosinophil progenitor module in HPC.
Genes
CLC, DTWD2, EPX, ERN1, EXD3, IL5RA, MS4A3, PRG2
Most correlated modules
- Mast Cell Differentiation · correlation 0.94
- Myeloid Lipid Signaling · correlation 0.89
- Mast Cell Basophil · correlation 0.87
- HPC Stemness Program · correlation 0.74
- Mast Cell Progenitor · correlation 0.72
- ER Protein Folding · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.