DUOX1 — Dual oxidase 1
DUOX1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUOX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, ELF2, EVI5 +23 more | View in SCUBA |
About the gene
| Synonyms | LNOX1, NOXEF1, THOX1 |
|---|---|
| Chromosome | 15: 45129933-45165576 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Oxidoreductase, Peroxidase |
| Biological process | Hydrogen peroxide, Thyroid hormones biosynthesis |
Function
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.