CD79A — CD79a molecule
CD79A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD79A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | ARID5A, CD52, CD74, CTSS, CYBA, HLA-DPA1, HLA-DPB1, HLA-DQA1 +9 more | View in SCUBA |
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CH25H, CHGB, DUOX1, ELF2, EVI5 +23 more | View in SCUBA |
| Hematopoietic progenitor cells | Pro-B Progenitor Lymphcyte development | ARPP21, CD79B, CYGB, DNTT, EBF1, FRMD4A, IL2RA, IL7R +4 more |
About the gene
| Synonyms | Ig-alpha, IGA, IGAlpha, MB-1, MB1 |
|---|---|
| Chromosome | 19: 41877279-41881372 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B- cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.