ELF2 — E74 like ETS transcription factor 2
ELF2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, EVI5 +23 more | View in SCUBA |
| Gamma-delta T cells | Innate Stress Signaling Inflammation | AKT3, B4GALT4, BCR, BLOC1S4, COL6A2, CREBRF, DGKQ, FAM53B +23 more | |
| Lymphatic endothelial | MAPK-ERK Signaling migration & adhesion | ARIH1, BRAF, CPNE8, DENND4A, FBXO11, FNDC3B, GRB10, NT5C2 +6 more | View in SCUBA |
| Macrophages | Chromatin Epigenetic Regulation Housekeeping | ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, FBXO34 +21 more | View in SCUBA |
| Neutrophils | Endosomal Vesicle Trafficking Vesicular traficking | DIP2B, JAK1, NRDC, OSBPL8, PCNX1, PICALM, SLC12A6, TBXAS1 +3 more |
About the gene
| Synonyms | EU32, NERF, NERF-1A, NERF-1B, NERF-2 |
|---|---|
| Chromosome | 4: 139028112-139177218 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter. Isoform 2 may function in repression of RUNX1-mediated transactivation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.