G2E3 — G2/M-phase specific E3 ubiquitin protein ligase
G2E3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
G2E3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | BEST4+ Survival Signaling Epithelial development | ABCC4, BCL2, CAMK1D, CNTRL, DEPTOR, FOXP2, GMNN, GSAP +14 more | View in SCUBA |
About the gene
| Synonyms | FLJ20333, KIAA1333, PHF7B |
|---|---|
| Chromosome | 14: 30559158-30620064 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Developmental protein, Transferase |
| Biological process | Apoptosis, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.