BEST4+ Survival Signaling
Gene co-expression module in Colonocytes
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 23 genes have a known function matching the annotation |
Why this annotation
This module is enriched in BEST4+ colonocytes (most genes 2–5x enriched in BEST4 subset) and contains genes associated with cell survival and identity maintenance: BCL2 (anti-apoptotic), DEPTOR (mTOR inhibitor, regulates cell growth/survival), GMNN (geminin, DNA replication licensing), WNK2 (kinase involved in ion transport), SLC4A7 (bicarbonate transporter), SORBS2 (cytoskeletal adaptor), RHOBTB3 (Rho GTPase), CAMK1D (calcium/calmodulin kinase), MYO10 (myosin). GMNN and MIS18BP1 have cell cycle licensing roles but the module is not a pure cell cycle module. The BEST4 enrichment and presence of BCL2, DEPTOR, SLC4A7 suggest this is a BEST4+ colonocyte survival/identity module, complementary to M1. The neighbor context (M1 is the canonical BEST4 identity module) supports this as a secondary BEST4+ program focused on survival signaling and ion transport regulation.
Genes
Most correlated modules
- BEST4+ Lipid Metabolism · correlation 0.86
- BEST4+ Colonocyte Identity · correlation 0.71
- DNA Replication S-phase · correlation 0.70
- Transcription-Coupled Splicing · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.