ABCC4 — ATP binding cassette subfamily C member 4
ABCC4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | EC Quiescence Identity Endothelial cell development | ARHGAP5, C1orf115, ENPP4, FAM107A, GIT2, IFNAR2, LRRFIP1, MSI2 +8 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | BMP7, EMID1, ETS1, GJA1, GNG2, LEF1, MFGE8, PAPLN +5 more | View in SCUBA |
| Macrophages | Transcriptional Regulation Housekeeping | ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2, FRMD4A +20 more | View in SCUBA |
About the gene
| Synonyms | EST170205, MOAT-B, MOATB, MRP4 |
|---|---|
| Chromosome | 13: 95019835-95301475 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.