FOXP2 — Forkhead box P2
FOXP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FOXP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | SATB2 colonic identity Epithelial development | C1orf21, PALS2, PDE3A, PRKG1, PRR5L, RNF152, SATB2 | View in SCUBA |
| Fibroblasts | Neural-crest Fibroblast Developmental | AMIGO2, C1orf54, CENPW, DCLK1, FLRT2, IGFBP4, KIAA0408, MAOB +8 more | View in SCUBA |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, HIF3A, HMCN1, KAT2B, MAP3K1 +11 more | View in SCUBA |
| Smooth muscle cells | Microfibrillar ECM Program ECM remodeling | ALDH1A1, CDC42EP3, FGL2, MAB21L2, MFAP2, NREP, OLFML3, PNCK +2 more | View in SCUBA |
About the gene
| Synonyms | CAGH44, SPCH1, TNRC10 |
|---|---|
| Chromosome | 7: 114086327-114693772 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.