FUT11 — Fucosyltransferase 11
FUT11 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FUT11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, GLIPR2 +17 more | |
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, GANAB, GLB1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Endosomal Actin Organization Cytoskeletal | ARHGEF2, ATF6B, CGGBP1, IARS2, ICE2, INPP5B, SH3BP2, SMC1A +7 more |
About the gene
| Synonyms | MGC33202 |
|---|---|
| Chromosome | 10: 73772276-73780251 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Protein O-fucosyltransferase that specifically catalyzes O- fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O- fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. Also shows minor alpha-(1,3)-fucosyltransferase activity toward activity toward biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.