BRD9 — Bromodomain containing 9
BRD9 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRD9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Autophagy Stress Response Stress | AKIRIN1, CDKN2AIP, DHX36, DNAJB2, FOXO3, MLXIP, ODF2L, PPP2R2A +11 more | |
| Mucosal-associated invariant T cell | Mucosal MAIT Homing migration & adhesion | BLK, CCR6, DSEL, ERN1, FUT7, LGALS3, LPAR6, LST1 +5 more |
About the gene
| Synonyms | FLJ13441, SMARCI2 |
|---|---|
| Chromosome | 5: 850291-892801 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
| Biological process | Transcription, Transcription regulation |
Function
Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA- histone contacts within a nucleosome in an ATP-dependent manner. Also orchestrates the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.