ER Protein Quality Control
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes ERGIC3, STT3A, GANAB, PRKCSH, OS9 define ER glycoprotein processing and quality control (ERAD). RETREG2 mediates ER-phagy. TAPBP (tapasin) links to MHC-I peptide loading in the ER. GLB1, GM2A, SLC15A3 add lysosomal processing. Together this module captures ER-to-lysosome protein quality control and glycoprotein maturation in macrophages.
Genes
ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB, GLB1, GM2A, KIAA2013, LAIR1, LRRC25, MAN1B1, OS9, PRKCSH, PTTG1IP, RETREG2, SLC15A3, SLC35F6, STT3A, TAPBP, TM9SF2, TMED4, TWF1, UBLCP1, UNC93B1
Most correlated modules
- Autophagy Vesicular Trafficking · correlation 0.97
- ER-Lysosome Trafficking · correlation 0.96
- Nuclear Pore Transport · correlation 0.96
- Myeloid Innate Signaling · correlation 0.96
- ER Membrane Homeostasis · correlation 0.95
- Glycogen Metabolism · correlation 0.95
- Central Carbon Metabolism · correlation 0.95
- Retromer Endosomal Sorting · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.