Vesicular Trafficking
Gene co-expression module in Colonocytes
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes EEA1 (early endosome), TRIP11 (Golgi), MGAT1 (N-glycosylation in Golgi), NUP62 (nuclear pore), AP1S2 (clathrin adaptor), PGGT1B (prenylation for membrane targeting), HEXA and GM2A (lysosomal enzymes), MFSD1 (lysosomal transporter) collectively define intracellular vesicular trafficking spanning endosomes, Golgi, and lysosomes. BRD9 and ZNF276 are peripheral. Uniform expression across subsets, moderate detection consistent with housekeeping trafficking function.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.97
- Stem Cell Epigenetic · correlation 0.94
- Ubiquitin-Proteasome System · correlation 0.90
- Mitochondrial Maintenance · correlation 0.86
- RNA Splicing Regulation · correlation 0.85
- BEST4 Colonocyte Identity · correlation 0.83
- Cellular Senescence · correlation 0.83
- ER Stress & UPR · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.