AP1S2 — Adaptor related protein complex 1 subunit sigma 2
AP1S2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AP1S2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-antagonizing Fibroblast Developmental | GREM1, HSPB6, IL33, MBP, NBEA, PBX3, RGMA, RGN +1 more | View in SCUBA |
| Glial cells | Glial Myelination Identity Myelination | CALM2, CD81, CD9, COMT, GPM6B, GSN, IGFBP7, LGALS1 +6 more | View in SCUBA |
| Smooth muscle cells | BMP-antagonist Niche Development | ARL4C, C3, CCBE1, CD74, CHRDL1, CISD1, GREM1, GREM2 +4 more | View in SCUBA |
About the gene
| Synonyms | MRX59, MRXS5, PGS, SIGMA1B |
|---|---|
| Chromosome | X: 15825806-15854931 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Protein transport, Transport |
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.