GANAB — Glucosidase II alpha subunit
GANAB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GANAB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Vesicular Trafficking Housekeeping | ADD1, ANAPC5, COPG1, EFCAB14, EXOC7, MAN2B2, MCM3AP, MED1 +10 more | |
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GLB1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoskeletal Organization Housekeeping | DDB1, HYOU1, IPO7, MYH9, NOLC1, NUMA1, PRPF8, SIN3A +4 more |
About the gene
| Synonyms | G2AN, GIIA, GluII, KIAA0088 |
|---|---|
| Chromosome | 11: 62624826-62646726 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Glycosidase, Hydrolase |
Function
Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.