GMPPA — GDP-mannose pyrophosphorylase A
GMPPA belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GMPPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | N-Glycosylation ER Stress Stress | CREB3, DNAJC10, GFPT1, SEC16A, SEC24D, SLC39A7, TMED9 | View in SCUBA |
About the gene
| Chromosome | 2: 219498865-219513898 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex. Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose. Together with GMPPB regulates GDP-alpha-D-mannose levels
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.