N-Glycosylation ER Stress
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes DNAJC10 (glycoprotein ERAD chaperone), GFPT1 (hexosamine/UDP-GlcNAc rate-limiting enzyme), GMPPA (GDP-mannose synthesis for N-glycosylation), SEC16A/SEC24D (COPII), TMED9 (COPI/COPII cargo receptor), SLC39A7 (ER zinc homeostasis for glycosylation enzymes), and CREB3 (ER stress TF) define a tight N-glycosylation substrate supply and ER quality control module. Strongly upregulated in UC/CD inflammation and reversed in UC remission, consistent with ER stress driven by inflammatory mucin demand in goblet cells.
Genes
CREB3, DNAJC10, GFPT1, GMPPA, SEC16A, SEC24D, SLC39A7, TMED9
Most correlated modules
- ER Targeting ERAD · correlation 0.92
- Protein trafficking & glycosylation · correlation 0.91
- Mucin Folding Machinery · correlation 0.91
- UPR Chaperone Response · correlation 0.91
- Mucin O-Glycosylation · correlation 0.90
- ER Protein Translocation · correlation 0.90
- Goblet Secretory Identity · correlation 0.89
- ER Chaperone Glycosylation · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.