GFPT1 — Glutamine--fructose-6-phosphate transaminase 1
GFPT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GFPT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | N-Glycosylation ER Stress Stress | CREB3, DNAJC10, GMPPA, SEC16A, SEC24D, SLC39A7, TMED9 | View in SCUBA |
| Macrophages | ER-Golgi Trafficking Vesicular traficking | B4GALT5, CDC27, CLCN3, CUL1, HPS3, KCTD20, PPTC7, PTPN9 +5 more | View in SCUBA |
About the gene
| Synonyms | GFA, GFAT, GFAT1, GFPT |
|---|---|
| Chromosome | 2: 69319780-69387250 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Aminotransferase, Transferase |
| Biological process | Biological rhythms |
Function
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.