GPR146 — G protein-coupled receptor 146
GPR146 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR146's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | GIMAP mediated permeability Mitochondrial & OxPhos | AGTRAP, CCNI, GIMAP1, GIMAP4, GIMAP7, HEBP1, LYL1, PSMB9 +2 more | View in SCUBA |
About the gene
| Synonyms | PGR8 |
|---|---|
| Chromosome | 7: 1044546-1059261 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G-protein coupled receptor required for the regulation of plasma cholesterol levels. Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.