GIMAP mediated permeability
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
The top three hub genes GIMAP4, GIMAP7, and GIMAP1 are GTPases of the immunity-associated protein family exclusively expressed in lymphocytes (T and NK cells) and are canonical T-cell survival markers. LYL1 is a hematopoietic/lymphoid transcription factor. PSMB9 is an immunoproteasome subunit induced in lymphocytes. UBE2L6 is an ISG15-conjugating enzyme enriched in immune cells. Despite uniform expression (suggesting possible ambient RNA), the GIMAP family dominance strongly indicates T-cell contamination signal in these lymphatic epithelial cells.
Genes
AGTRAP, CCNI, GIMAP1, GIMAP4, GIMAP7, GPR146, HEBP1, LYL1, PSMB9, UBE2L6, ZNF22
Most correlated modules
- Metabolic Housekeeping · correlation 0.88
- Oxidative Stress Response · correlation 0.87
- Mitochondrial OxPhos Complex · correlation 0.87
- ER-Lysosomal Processing · correlation 0.83
- Mitochondrial OxPhos Complex · correlation 0.83
- Housekeeping Mixed · correlation 0.82
- Integrin Focal Adhesion · correlation 0.82
- Fatty Acid Oxidation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.