PSMB9 — Proteasome 20S subunit beta 9
PSMB9 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMB9's module in each cell type
About the gene
| Synonyms | beta1i, LMP2, PSMB6i, RING12 |
|---|---|
| Chromosome | 6: 32844136-32859851 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease, Threonine protease |
| Biological process | Host-virus interaction, Immunity |
Function
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP- dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.