AGTRAP — Angiotensin II receptor associated protein
AGTRAP belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGTRAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitochondrial Oxidative Stress Stress | AP2M1, ECHS1, ECSCR, EDF1, EIF5A, NEDD8, PARK7, PHPT1 +5 more | View in SCUBA |
| Gamma-delta T cells | Effector IFN Response cytotoxicity | ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM1, IFITM2 +9 more | |
| Lymphatic endothelial | GIMAP mediated permeability Mitochondrial & OxPhos | CCNI, GIMAP1, GIMAP4, GIMAP7, GPR146, HEBP1, LYL1, PSMB9 +2 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, ANXA2, ANXA4, C15orf48, CD44, CD9, DRAM1 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Ribosome Mitochondrial & OxPhos | BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, DYNC1I2, FOXN2 +22 more |
About the gene
| Synonyms | ATRAP |
|---|---|
| Chromosome | 1: 11736084-11754802 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II- stimulated transcriptional activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.