Mature enterocyte differentiation
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Mature colonocyte/enterocyte differentiation program. Supporting genes: brush border EPS8L2, apical xenobiotic efflux transporter ABCC2, diamine oxidase AOC1, MYLK, ACSF2 and PFKFB4 metabolic genes, and MXI1, a MYC antagonist marking post-mitotic differentiation. Expression is broad and uniform with no subset enrichment. It is a neighbor of the other absorptive/metabolic modules in this batch, consistent with a terminal absorptive state.
Genes
ABCC2, ACSF2, AOC1, CDC14A, CEP350, EEPD1, EPS8L2, GRAMD1C, MXI1, MYLK, PFKFB4, PHLPP2, PTTG1IP, STK17B
Most correlated modules
- Villus-tip enterocyte transport · correlation 0.92
- Crypt-top colonocyte · correlation 0.92
- Amino acid absorption · correlation 0.90
- Brush-border Nutrient Uptake · correlation 0.89
- Chylomicron apolipoprotein assembly · correlation 0.88
- Amino acid absorption · correlation 0.85
- Enterocyte lipid trafficking · correlation 0.85
- Long-gene Nuclear Transcripts · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.