GREM2 — Gremlin 2, DAN family BMP antagonist
GREM2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GREM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC electrophysiological machinery Gut motility | ADRB3, CAP2, CDCA7L, CSRP2, DTNA, LGI1, LMO3, MEF2C +5 more | View in SCUBA |
| Smooth muscle cells | BMP-antagonist Niche Development | AP1S2, ARL4C, C3, CCBE1, CD74, CHRDL1, CISD1, GREM1 +4 more | View in SCUBA |
About the gene
| Synonyms | CKTSF1B2, DAND3, FLJ21195, Prdc |
|---|---|
| Chromosome | 1: 240489573-240612155 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Cytokine, Developmental protein, Heparin-binding |
Function
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.