GREM1 — Gremlin 1, DAN family BMP antagonist
GREM1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GREM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | BMP-antagonizing Fibroblast Developmental | AP1S2, HSPB6, IL33, MBP, NBEA, PBX3, RGMA, RGN +1 more | View in SCUBA |
| Smooth muscle cells | BMP-antagonist Niche Development | AP1S2, ARL4C, C3, CCBE1, CD74, CHRDL1, CISD1, GREM2 +4 more | View in SCUBA |
About the gene
| Synonyms | CKTSF1B1, CRAC1, DAND2, DRM, gremlin, HMPS |
|---|---|
| Chromosome | 15: 32718004-32745106 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
Function
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.