KCNK6 — Potassium two pore domain channel subfamily K member 6
KCNK6 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNK6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | ER Targeting ERAD Protein processing & ER | AP3S1, ARFGAP3, ARMCX3, HM13, PRRC1, SELENOS, SRPRA, TMCO3 +1 more | View in SCUBA |
About the gene
| Synonyms | K2p6.1, TWIK-2 |
|---|---|
| Chromosome | 19: 38319845-38332076 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (By similarity). Does not display channel activity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.