SELENOS — Selenoprotein S

SELENOS belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SELENOS's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Effector activation NFkB TCR/AP1/NFKb pathway	ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more	View in SCUBA
Endothelial	Actin Cytoskeletal Remodeling Cytoskeletal	ACTB, ACTG1, ARF1, ARPC5L, CFL1, CYCS, DNAJB11, DNAJC1 +5 more	View in SCUBA
Fibroblasts	Inflammatory Fibroblast Activation Inflammatory	CISD1, HRH1, HSPA5, ITGA5, LHFPL2, MAPKAPK2, PDPN, PLAUR +4 more	View in SCUBA
Gamma-delta T cells	RNA Processing RNA processing & translation	ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, BUD23, CIAO2B, E2F4, ELAVL1 +12 more
Goblet cells	ER Targeting ERAD Protein processing & ER	AP3S1, ARFGAP3, ARMCX3, HM13, KCNK6, PRRC1, SRPRA, TMCO3 +1 more	View in SCUBA
Innate lymphoid cells	NK Receptor Signaling Cytotoxicity	B2M, CD48, CLEC2B, DCK, FCER1G, FKBP11, GPR108, HLA-A +12 more	View in SCUBA
Pericytes	ER Stress Response Stress	ARF4, HSPA5, LDHA, PDLIM1, RAP1B, REXO2, SEC61G, SNX6	View in SCUBA

About the gene

Synonyms	AD-015, MGC2553, SBBI8, SELS, SEPS1, VIMP
Chromosome	15: 101270817-101277500
Predicted location	Membrane
Essential gene	No
Protein class	Predicted membrane proteins

Function

Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.