HM13 — Histocompatibility minor 13
HM13 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HM13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | ER Targeting ERAD Protein processing & ER | AP3S1, ARFGAP3, ARMCX3, KCNK6, PRRC1, SELENOS, SRPRA, TMCO3 +1 more | View in SCUBA |
| Innate lymphoid cells | JAK-STAT Cytokine Signaling Inflammation | AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2 +23 more | View in SCUBA |
| Macrophages | Phagocytic Endolysosomal Lysosomal & pahgocytosis | ABHD2, ACTN4, AP3S1, ARF6, ATP6V1B2, CD151, CERS2, CNIH1 +27 more | View in SCUBA |
About the gene
| Synonyms | dJ324O17.1, H13, IMP1, IMPAS, PSENL3, PSL3, SPP, SPPL1 |
|---|---|
| Chromosome | 20: 31514410-31577923 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Hydrolase, Protease |
Function
Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.