SRPRA — SRP receptor subunit alpha
SRPRA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRPRA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, HOOK2 +12 more | |
| Goblet cells | ER Targeting ERAD Protein processing & ER | AP3S1, ARFGAP3, ARMCX3, HM13, KCNK6, PRRC1, SELENOS, TMCO3 +1 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3 +22 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Organization Cytoskeletal | ARAP2, CHD8, CTNNB1, DYNC1H1, EP400, NFATC2, RASSF2, RNF4 +4 more |
About the gene
| Synonyms | SR-alpha, Sralpha, SRP-alpha, SRPR |
|---|---|
| Chromosome | 11: 126262938-126269144 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Receptor |
Function
Component of the signal recognition particle (SRP) complex receptor (SR). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54. SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.