ARMCX3 — Armadillo repeat containing X-linked 3
ARMCX3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARMCX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | ER Targeting ERAD Protein processing & ER | AP3S1, ARFGAP3, HM13, KCNK6, PRRC1, SELENOS, SRPRA, TMCO3 +1 more | View in SCUBA |
| Innate lymphoid cells | Lymphocyte Apoptosis Regulation Immune regulation | ANP32B, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1, LEPROTL1 +14 more | View in SCUBA |
| Macrophages | RNA Splicing Processing Housekeeping | CIRBP, ELK4, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL, HP1BP3 +13 more | View in SCUBA |
About the gene
| Synonyms | ALEX3, GASP6 |
|---|---|
| Chromosome | X: 101622797-101627843 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.